Publications

Complete assembly, annotation of virulence genes and CRISPR editing of the genome of Leishmania amazonensis PH8 strain.

Wanessa Moreira Goes, Carlos Rodolpho Ferreira Brasil, João Luis Reis-Cunha, Anderson Coqueiro-dos-Santos, Viviane Grazielle-Silva, Júlia de Souza Reis, Tatiane Cristina Souto, Maria Fernanda Laranjeira-Silva, Daniella Castanheira Bartholomeu, Ana Paula Fernandes, Santuza Maria Ribeiro Teixeira

Reporter gene systems: A powerful tool for Leishmania studies

Romário L. Boy, Ahyun Hong, Juliana I. Aoki, Lucile Maria Floeter-Winter, Maria Fernanda Laranjeira-Silva

Novel insights into parasite dynamics for leishmaniasis treatment

Maria Fernanda Laranjeira da Silva

Lipid and fatty acid metabolism in trypanosomatids

Giovana P. de Aquino, Marco Antonio M. Gomes, Roberto K. Salinas, Maria Fernanda Laranjeira-Silva

One health approach to leishmaniases: understanding the disease dynamics through diagnostic tools

Ahyun Hong, Ricardo A. Zampieri, Jeffrey J. Shaw, Lucile Maria Floeter-Winter, Maria Fernanda Laranjeira-Silva

Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background

Juliana I. Aoki, Sandra M. Muxel, Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Karl E. Müller, Audun H. Nerland, Lucile Maria Floeter-Winter

Iron and heme metabolism at the Leishmania-host interface

Maria Fernanda Laranjeira-Silva, Iqbal Hamza, José M. Pérez-Victoria

In vivo infection with Leishmania amazonensis to evaluate parasite virulence in mice

Juliana I. Aoki, Ahyun Hong, Ricardo A. Zampieri, Lucile Maria Floeter-Winter, Maria Fernanda Laranjeira-Silva

The impact of arginase activity on virulence factors of Leishmania amazonensis.

Juliana I. Aoki, Maria Fernanda Laranjeira-Silva, Sandra M. Muxel, Lucile Maria Floeter-Winter

Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis is a ROS-induced essential enzyme that regulates virulence.

Lucia Xiang, Maria Fernanda Laranjeira- Silva, Fernando Y. Maeda, Jason Hauzel, Norma W. Andrews, Bidyottam Mittra

Intracellular iron availability modulates the requirement for Leishmania Iron Regulator 1 (LIR1) during macrophage infections

Amrita Sarkar, Norma W. Andrews, Maria Fernanda Laranjeira-Silva

A MFS-like plasma membrane transporter required for Leishmania virulence protects the parasites from iron toxicity

Maria Fernanda Laranjeira-Silva, Wanpeng Wang, Tamika K. Samuel, Fernando Y. Maeda, Vladimir Michailowsky, Iqbal Hamza, Zhongchi Liu, Norma W. Andrews

Quantification of intracellular growth inside macrophages is a fast and reliable method for assessing the virulence of Leishmania parasites

Amrita Sarkar, Yousuf A. Khan, Maria Fernanda Laranjeira-Silva, Norma W. Andrews, Bidyottam Mittra

Arginine and polyamines fate in Leishmania infection

Sandra M. Muxel, Juliana I. Aoki, Juliane C. R. Fernandes, Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Stephanie M. Acuña, Karl E. Müller, Rubia H. Vanderlinde, Lucile Maria Floeter-Winter

Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis

Stephanie M. Acuña, Juliana I. Aoki, Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Juliane C. R. Fernandes, Sandra M. Muxel, Lucile Maria Floeter-Winter

RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginase-dependent gene expression regulation

Juliana I. Aoki, Sandra M. Muxel, Ricardo A. Zampieri, Maria Fernanda Laranjeira-Silva, Karl E. Müller, Audun H. Nerland, Lucile Maria Floeter-Winter

The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence

Bidyottam Mittra, Maria Fernanda Laranjeira-Silva, Danilo C. Miguel, Juliana P. B. de Menezes, Norma W. Andrews

Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism

Sandra M. Muxel, Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Lucile Maria Floeter-Winter

Functional validation of miRNA-mRNA interactions in macrophages by inhibition/competition assays based in transient transfection

Sandra M. Muxel, Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Juliana I. Aoki, Stephanie M. Acuña, Lucile Maria Floeter-Winter

Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins

Juliana P. B. de Menezes, Amrita Koushik, Satarupa Das, Can Guven, Ariel Siegel, Maria Fernanda Laranjeira-Silva, Wolfgang Losert, Norma W. Andrews

The RelA/cRel Nuclear Factor-KB (NF-KB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages

Sandra M. Muxel, Maria Fernanda Laranjeira-Silva, Claudia E. C. Sousa, Lucile Maria Floeter-Winter, Regina P. Markus

High resolution melting analysis targeting hsp70 as a fast and efficient method for the discrimination of Leishmania species

Ricardo A. Zampieri, Maria Fernanda Laranjeira-Silva, Sandra M. Muxel, Ana Carolina S. de Lima, Jeffrey J. Shaw, Lucile Maria Floeter-Winter

A trypanosomatid iron transporter that regulates mitochondrial function is required for Leishmania amazonensis virulence

Bidyottam Mittra, Maria Fernanda Laranjeira-Silva, Juliana P. B. de Menezes, Jennifer Jensen, Vladimir Michailowsky, Norma W. Andrews

Melatonin attenuates Leishmania (L.) amazonensis infection by modulating arginine metabolism

Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Sandra M. Muxel, Lucile Maria Floeter-Winter, Regina P. Markus

Capillary electrophoresis reveals polyamine metabolism modulation in Leishmania (Leishmania) amazonensis wild-type and arginase knockout mutants under arginine starvation

Emerson A. Castilho-Martins, Gisele A. B. Canuto, Sandra M. Muxel, Maria Fernanda Laranjeira-Silva, Lucile Maria Floeter-Winter, Carmen del Aguila, Ángeles López-Gonzálvez, Coral Barbas

Arginase in Leishmania

Maria Fernanda Laranjeira-Silva, Lucile M. Floeter-Winter

Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity

Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Sandra M. Muxel, Stephen M. Beverley, Lucile M. Floeter-Winter

Footprints of a trypanosomatid RNA world: pre-small subunit rRNA processing by spliced leader addition trans-splicing

Mario Mayer, Marco G. dos Santos, Maria Fernanda Laranjeira-Silva, Lucile Maria Floeter-Winter

Axenic Leishmania amazonensis promastigotes sense both the external and internal arginine pool distinctly regulating the two transporter-coding genes

Emerson A. Castilho-Martins, Maria Fernanda Laranjeira-Silva, Marcos G. dos Santos, Sandra M. Muxel, Lucile M. Floeter-Winter

Correlation of meta 1 expression with culture stage, cell morphology and infectivity in Leishmania (Leishmania) amazonensis promastigotes

Marcos G. dos Santos, Maria Fernanda Laranjeira-Silva, Ricardo A. Zampieri, Rafaella M. Lafraia, Lucile Maria Floeter-Winter

Biochemical characterization of serine transport in Leishmania (Leishmania) amazonensis

Marcos G. dos Santos, Lisvane S. Paes, Ricardo A. Zampieri, Maria Fernanda Laranjeira-Silva, Ariel M. Silber, Lucile Maria Floeter-Winter

Biochemical and biophysical properties of a highly active recombinant arginase from Leishmania (Leishmania) amazonensis and subcellular localization of native enzyme.

Edson R. da Silva, Maria Fernanda Laranjeira-Silva, Hannes Fischer, Renato A. Mortara, Mario G. Mayer, Karine Framesqui, Ariel M. Sielber, Lucile Maria Floeter-Winter